Oxidative stress and signal transduction pathways in alcoholic liver disease.

  title={Oxidative stress and signal transduction pathways in alcoholic liver disease.},
  author={Tom{\'a}{\vs} Zima and Marta Kalousov{\'a}},
  journal={Alcoholism, clinical and experimental research},
  volume={29 11 Suppl},
Ethanol is linked to several pathologies like alcohol liver injury, neurotoxicity, cardiomyopathy, fetal alcoholic syndrome or cancer. It is generally accepted that oxidative stress plays a central role in their pathogenesis. After chronic and excessive consumption, alcohol may accelerate oxidative mechanisms both directly via increased production of reactive oxygen species and indirectly by impairing protective mechanisms against them. Ethanol, its metabolites arising during its metabolic… CONTINUE READING
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