Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson's disease.

@article{Samuele2005OxidativeSA,
  title={Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson's disease.},
  author={Alberta Samuele and Anna Mangiagalli and M T Armentero and Roberto Fancellu and Eleonora Bazzini and Mariapia Vairetti and Andrea Ferrigno and Plinio Richelmi and Giuseppe Nappi and Fabio Blandini},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1741 3},
  pages={325-30}
}
Wilson's disease (WD) is an inherited disorder, characterized by selective copper deposition in liver and brain, chronic hepatitis and extra-pyramidal signs. In this study, we investigated changes of biochemical markers of oxidative stress and apoptosis in liver, striatum and cerebral cortex homogenates from Long-Evans Cinnamon (LEC) rats, a mutant strain isolated from Long Evans (LE) rats, in whom spontaneous hepatitis develops shortly after birth. LEC and control (LE) rats at 11 and 14 weeks… CONTINUE READING