Oxidative stress and neuronal death/survival signaling in cerebral ischemia

  title={Oxidative stress and neuronal death/survival signaling in cerebral ischemia},
  author={Atsushi Saito and Carolina Magdalene Maier and Purnima Narasimhan and Tatsuro Nishi and Yun Seon Song and Fengshan Yu and Jing Liu and Yong-Sun Lee and Chikako Nito and Hiroshi Kamada and R L Dodd and Lily B. Hsieh and Benjamin G. Hassid and Esther E. Kim and Maricela Gonz{\'a}lez and Pak Hoo Chan},
  journal={Molecular Neurobiology},
It has been demonstrated by numerous studies that apoptotic cell death pathways are implicated in ischemic cerebral injury in ischemia models in vivo. Experimental ischemia and reperfusion models, such as transient focal/global ischemia in rodents, have been thoroughly studied and the numerous reports suggest the involvement of cell survival/death signaling pathways in the pathogenesis of apoptotic cell death in ischemic lesions. In these models, reoxygenation during reperfusion provides oxygen… CONTINUE READING


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