Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates.

@article{Daiber2004OxidativeSA,
  title={Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates.},
  author={Andreas Daiber and Matthias Oelze and Meike Coldewey and Markus M Bachschmid and Philip Wenzel and Karsten Sydow and Maria C Wendt and Andrei L. Kleschyov and Dirk Stalleicken and Volker Ullrich and Alexander Muelsch and Thomas F. M{\"u}nzel},
  journal={Molecular pharmacology},
  year={2004},
  volume={66 6},
  pages={1372-82}
}
Mitochondrial aldehyde dehydrogenase (ALDH-2) was recently identified to be essential for the bioactivation of glyceryl trinitrate (GTN). Here we assessed whether other organic nitrates are bioactivated by a similar mechanism. The ALDH-2 inhibitor benomyl reduced the vasodilator potency, but not the efficacy, of GTN, pentaerythritol tetranitrate (PETN), and pentaerythritol trinitrate in phenylephrine-constricted rat aorta, whereas vasodilator responses to isosorbide dinitrate, isosorbide-5… CONTINUE READING