Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone.

@article{Wang2001OxidativeSA,
  title={Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone.},
  author={Yi-ming Wang and Chung Choo Lee and Weng Cheng Chang and Hsiou-chi Liou and Ye Shih Ho},
  journal={Toxicology letters},
  year={2001},
  volume={122 2},
  pages={157-69}
}
Pentachlorophenol (PCP) is a pesticide used worldwide in industrial and domestic applications. It is used extensively as biocide and wood preservatives. Metabolic studies carried out in rodents and human liver homogenates have indicated that PCP undergoes oxidative dechlorination to form tetrachlorohydroquinone (TCHQ). Free radical catalyzed tissue injury is thought to play a fundamental role in human disease. In the present study, we examined the effects of PCP and TCHQ on the induction of… CONTINUE READING

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