Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance.

@article{Murdolo2013OxidativeSA,
  title={Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance.},
  author={Giuseppe Murdolo and Marta Piroddi and Francesca Luchetti and Cristina Tortoioli and Barbara Canonico and Chiara Zerbinati and Francesco Galli and Luigi Iuliano},
  journal={Biochimie},
  year={2013},
  volume={95 3},
  pages={585-94}
}
Obesity has been proposed as an energy balance disorder in which the expansion of adipose tissue (AT) leads to unfavorable health outcomes. Even though adiposity represents the most powerful driving force for the development of insulin resistance (IR) and type 2 diabetes, mounting evidence points to "adipose dysregulation", rather than fat mass accrual per se, as a key pathophysiological trigger of the obesity-linked metabolic complications. The dysfunctional fat, besides hypertrophic adipose… CONTINUE READING