Oxidative stress and heart failure

  title={Oxidative stress and heart failure},
  author={Neelam Singh and A. Dhalla and C. Seneviratne and P. Singal},
  journal={Molecular and Cellular Biochemistry},
  • Neelam Singh, A. Dhalla, +1 author P. Singal
  • Published 2004
  • Medicine
  • Molecular and Cellular Biochemistry
  • Various abnormalities have been implicated in the transition of hypertrophy to heart failure but the exact mechanism is still unknown. Thus heart failure subsequent to hypertrophy remains a major clinical problem. Recently, oxidative stress has been suggested to play a critical role in the pathogenesis of heart failure. Here we describe antioxidant changes as well as their significance during hypertrophy and heart failure stages. Heart hypertrophy in rats and guinea pigs, in response to… CONTINUE READING
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