Oxidative stress and disuse muscle atrophy.

  title={Oxidative stress and disuse muscle atrophy.},
  author={Scott K. Powers and Andreas N. Kavazis and Joseph M. McClung},
  journal={Journal of applied physiology},
  volume={102 6},
Skeletal muscle inactivity is associated with a loss of muscle protein and reduced force-generating capacity. This disuse-induced muscle atrophy results from both increased proteolysis and decreased protein synthesis. Investigations of the cell signaling pathways that regulate disuse muscle atrophy have increased our understanding of this complex process. Emerging evidence implicates oxidative stress as a key regulator of cell signaling pathways, leading to increased proteolysis and muscle… CONTINUE READING