Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm.

@article{Mezzetti2000OxidativeSA,
  title={Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm.},
  author={Andrea Mezzetti and Francesco Cipollone and Franco Cuccurullo},
  journal={Cardiovascular research},
  year={2000},
  volume={47 3},
  pages={475-88}
}
Long-term vascular complications still represent the main cause of morbidity and mortality in diabetic patients. Although randomized long-term clinical studies comparing the effects of conventional and intensive therapy have demonstrated a clear link between hyperglycemia and the development of complications of diabetes, they have not defined the mechanism through which excess glucose results in tissue damage. Evidence has accumulated indicating that oxidative stress may play a key role in the… CONTINUE READING
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