Oxidative stress and cancer pain.

  title={Oxidative stress and cancer pain.},
  author={Robert G. Ungard and Eric P. Seidlitz and Gurmit Singh},
  journal={Canadian journal of physiology and pharmacology},
  volume={91 1},
Breast cancers are the most common source of metastases to bone, of which cancer-induced bone pain is a frequent pathological feature. Cancer-induced bone pain is a unique pain state with multiple determinants that remains to be well understood and managed. Current standard treatments are limited by dose-dependent side effects that can reduce the quality of life of patients. Glutamate is a neurotransmitter and bone cell-signalling molecule that is released via the system x(c)(-) cystine… CONTINUE READING