Oxidative stress and cancer: have we moved forward?

@article{Halliwell2007OxidativeSA,
  title={Oxidative stress and cancer: have we moved forward?},
  author={Barry Halliwell},
  journal={The Biochemical journal},
  year={2007},
  volume={401 1},
  pages={
          1-11
        }
}
'Reactive species' (RS) of various types are formed in vivo and many are powerful oxidizing agents, capable of damaging DNA and other biomolecules. Increased formation of RS can promote the development of malignancy, and the 'normal' rates of RS generation may account for the increased risk of cancer development in the aged. Indeed, knockout of various antioxidant defence enzymes raises oxidative damage levels and promotes age-related cancer development in animals. In explaining this, most… 
View on PubMed
biochemj.org
1,209 Citations
Highly Influential Citations
43
Background Citations
557
Methods Citations
9
Results Citations
8

Figures from this paper

1,209 Citations

Oxidative stress in environmental-induced carcinogenesis.
Reactive species: a cell damaging rout assisting to chemical carcinogens.
Roles of oxidative stress in the development and progression of breast cancer.
TLDR
In this review, free radicals as oxidizing agents, antioxidants as the immune system, and the role of oxidative stress in cancer, particularly breast cancer, have been investigated in the hope that better identification of the factors involved in the occurrence and spread of cancer will improve the identification of treatment goals.
Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer
TLDR
It is argued that modulation of redox biochemistry represents a fruitful approach to cancer prevention and may also prevent cancer by initiating the death of the transformed cell via apoptosis or necrosis.
The differential role of reactive oxygen species in early and late stages of cancer.
  • M. Assi
  • Biology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2017
TLDR
Antioxidants should be prohibited in patients with advanced stages of cancer and/or undergoing anticancer therapies, because some polyphenols allow them to selectively recognize tumor cells, and results are encouraging, which may revolutionize the conventional use of antioxidants in cancer.
Oxidative Stress, Antioxidant and Cancer
TLDR
In vitro and in vivo data suggested that antioxidants inhibit the growth of tumor cells, however, clinical studies did not prove these benefits, neither carcinogenesis prevention nor efficacy of cancer treatments.
Oxidative damage and carcinogenesis
TLDR
Oxygen is an essential element to conduct life processes but some of the metabolic byproducts e.g. reactive oxygen species, are toxic for living organisms and ROS are considered as a significant class of carcinogens participating in cancer initiation, promotion and progression.
Oxidative Stress and Drug Resistance in Cancer
TLDR
Strategies to modulate cellular adaptation to oxidative stress may be used as an effective approach to overcome drug resistance in cancer cells under intrinsic stress.
Oxidative stress: development and progression of breast cancer:review article
the undisciplined growth of cells which inspires the development of tumors and initiates the progression of carcinogenesis. The im-portance of ROS on breast cancer development and etiology is being…
The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC)
TLDR
The evidence that links redox stress to the development of CRC is demonstrated and the most up-to-date information is assimilated that would facilitate future investigation on CRC-associated redox biology.
...
...

References

SHOWING 1-10 OF 183 REFERENCES
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
Oxidative DNA damage and disease: induction, repair and significance.
Effect of diet on cancer development: is oxidative DNA damage a biomarker?
ROS stress in cancer cells and therapeutic implications.
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
TLDR
It is shown that mice lacking Prdx1 are viable and fertile but have a shortened lifespan owing to the development beginning at about 9 months of severe haemolytic anaemia and several malignant cancers, both of which are also observed at increased frequency in heterozygotes.
Persistent oxidative stress in human colorectal carcinoma, but not in adenoma.
The role of oxidative stress in carcinogenesis.
TLDR
This review examines the evidence of cellular oxidants' involvement in the carcinogenesis process, and focuses on the mechanisms for production, cellular damage produced, and the role of signaling cascades by reactive oxygen species.
Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity.
  • J. Doroshow
  • Biology
    Journal of the National Cancer Institute
  • 2006
TLDR
ROS is a complex and interactive series of proteins and small molecules — including members of the superoxide dismutase, glutathione peroxidase, and peroxiredoxin gene families, as well as catalase — that ultimately reduce O 2 − and H 2 O 2 (or lipid peroxides) to non.
Reactive oxygen species in tumor progression.
  • P. Storz
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 2005
TLDR
The finding that a diet rich in antioxidants or the elimination of ROS by antioxidant compounds prevents the development of certain cancers provided the setting for subsequent investigation of the tumorigenic actions of reactive oxygen species.
Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer.
TLDR
ROS and RNS could contribute to the initiation of cancer, in addition to being important in the promotion and progression phases, as evidence is growing that antioxidants may prevent or delay the onset of some types of cancer.
...
...