Oxidative stress and cancer: have we moved forward?

  title={Oxidative stress and cancer: have we moved forward?},
  author={Barry Halliwell},
  journal={The Biochemical journal},
  volume={401 1},
'Reactive species' (RS) of various types are formed in vivo and many are powerful oxidizing agents, capable of damaging DNA and other biomolecules. Increased formation of RS can promote the development of malignancy, and the 'normal' rates of RS generation may account for the increased risk of cancer development in the aged. Indeed, knockout of various antioxidant defence enzymes raises oxidative damage levels and promotes age-related cancer development in animals. In explaining this, most… 

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