Oxidative stress and cancer: have we moved forward?

@article{Halliwell2007OxidativeSA,
  title={Oxidative stress and cancer: have we moved forward?},
  author={B. Halliwell},
  journal={The Biochemical journal},
  year={2007},
  volume={401 1},
  pages={
          1-11
        }
}
  • B. Halliwell
  • Published 2007
  • Chemistry, Medicine
  • The Biochemical journal
'Reactive species' (RS) of various types are formed in vivo and many are powerful oxidizing agents, capable of damaging DNA and other biomolecules. Increased formation of RS can promote the development of malignancy, and the 'normal' rates of RS generation may account for the increased risk of cancer development in the aged. Indeed, knockout of various antioxidant defence enzymes raises oxidative damage levels and promotes age-related cancer development in animals. In explaining this, most… Expand
View on PubMed
biochemj.org
1,159 Citations
Highly Influential Citations
40
Background Citations
514
Methods Citations
8
Results Citations
9

1,159 Citations

Citation Type

Citation Type

Oxidative stress in environmental-induced carcinogenesis.
TLDR
It is important to remark that, in agreement with present knowledge, oxidative/nitrosative/metabolic stress, inflammation, senescence, and cancer are linked concepts that must be discussed in a coordinated manner. Expand
Reactive species: a cell damaging rout assisting to chemical carcinogens.
TLDR
The role of oxidative stress in chemically induced cancer development and progression is discussed and several exocyclic DNA adducts represent secondary DNA damage caused by products of lipid peroxidation in the course of oxidative cellular stress. Expand
Roles of oxidative stress in the development and progression of breast cancer.
TLDR
In this review, free radicals as oxidizing agents, antioxidants as the immune system, and the role of oxidative stress in cancer, particularly breast cancer, have been investigated in the hope that better identification of the factors involved in the occurrence and spread of cancer will improve the identification of treatment goals. Expand
Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer
TLDR
It is argued that modulation of redox biochemistry represents a fruitful approach to cancer prevention and may also prevent cancer by initiating the death of the transformed cell via apoptosis or necrosis. Expand
The differential role of reactive oxygen species in early and late stages of cancer.
  • M. Assi
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2017
TLDR
Antioxidants should be prohibited in patients with advanced stages of cancer and/or undergoing anticancer therapies, because some polyphenols allow them to selectively recognize tumor cells, and results are encouraging, which may revolutionize the conventional use of antioxidants in cancer. Expand
Oxidative Stress, Antioxidant and Cancer
TLDR
In vitro and in vivo data suggested that antioxidants inhibit the growth of tumor cells, however, clinical studies did not prove these benefits, neither carcinogenesis prevention nor efficacy of cancer treatments. Expand
Oxidative stress in breast and gynaecological carcinogenesis
TLDR
Results indicate that in breast cancer and endometriosis-associated ovarian cancer, a high level of ROS-derived DNA damage could be significant factor in the initiation stage of carcinogenesis, whereas in later stages carcinomas benefit from lower ROS levels that support tumour growth and survival via cellular signalling. Expand
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD. Expand
Oxidative damage and carcinogenesis
TLDR
Oxygen is an essential element to conduct life processes but some of the metabolic byproducts e.g. reactive oxygen species, are toxic for living organisms and ROS are considered as a significant class of carcinogens participating in cancer initiation, promotion and progression. Expand
Oxidative Stress and Drug Resistance in Cancer
Increased generation of reactive oxygen species (ROS) is observed in many types of cancer cells. Besides the well-recognized effect of ROS in causing mutations and promoting cancer cell growth,… Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 176 REFERENCES
Oxidative DNA damage and disease: induction, repair and significance.
TLDR
The weight of evidence strongly suggests a link between such damage and the pathogenesis of disease, and the role of 8-OH-dG in disease, although exact roles remain to be elucidated. Expand
Effect of diet on cancer development: is oxidative DNA damage a biomarker?
  • B. Halliwell
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 2002
TLDR
In well-nourished human volunteers, fruits and vegetables have been shown to decrease oxidative DNA damage in several studies, but data from short-term human intervention studies suggest that the protective agents are not vitamin C, vitamin E, beta-carotene, or flavonoids. Expand
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
TLDR
This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors. Expand
ROS stress in cancer cells and therapeutic implications.
  • H. Pelicano, D. Carney, P. Huang
  • Biology, Medicine
  • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • 2004
TLDR
ROS stress in cancer cells is reviewed, its underlying mechanisms and relationship with mitochondrial malfunction and alteration in drug sensitivity are reviewed, and new therapeutic strategies that take advantage of increased ROS in cancer Cells to enhance therapeutic activity and selectivity are suggested. Expand
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
TLDR
It is shown that mice lacking Prdx1 are viable and fertile but have a shortened lifespan owing to the development beginning at about 9 months of severe haemolytic anaemia and several malignant cancers, both of which are also observed at increased frequency in heterozygotes. Expand
Nitrative DNA damage in inflammation and its possible role in carcinogenesis.
TLDR
The role in carcinogenesis of nitrative damage to nucleic acids, DNA and RNA, which occurs during inflammation through the generation of reactive nitrogen species, such as peroxynitrite, nitroxyl, and nitrogen dioxide, is reviewed. Expand
Persistent oxidative stress in human colorectal carcinoma, but not in adenoma.
TLDR
It is concluded that colorectal carcinoma, but not adenoma cells, are exposed to more oxidative stress than their corresponding nontumorous epithelial cells, regardless of clinical stage and histology, and further that the oxidative stress in carcinoma cells might stimulate cellular proliferation. Expand
Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity.
  • J. Doroshow
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 2006
TLDR
ROS is a complex and interactive series of proteins and small molecules — including members of the superoxide dismutase, glutathione peroxidase, and peroxiredoxin gene families, as well as catalase — that ultimately reduce O 2 − and H 2 O 2 (or lipid peroxides) to non. Expand
The role of oxidative stress in carcinogenesis.
TLDR
This review examines the evidence of cellular oxidants' involvement in the carcinogenesis process, and focuses on the mechanisms for production, cellular damage produced, and the role of signaling cascades by reactive oxygen species. Expand
Reactive oxygen species in tumor progression.
  • P. Storz
  • Chemistry, Medicine
  • Frontiers in bioscience : a journal and virtual library
  • 2005
TLDR
The finding that a diet rich in antioxidants or the elimination of ROS by antioxidant compounds prevents the development of certain cancers provided the setting for subsequent investigation of the tumorigenic actions of reactive oxygen species. Expand
...
1
2
3
4
5
...