Oxidative stress and autophagy: mediators of synapse growth?


Many neurodegenerative conditions have oxidative stress burdens where levels of reactive oxygen species (ROS) exceed the antioxidant capacity of the neuron. ROS can induce wide-ranging damage in a cell and this is prevented by the activation of antioxidant responses including autophagy. Jun-kinase (JNK) is stimulated by ROS and mediates antioxidant… (More)
DOI: 10.4161/auto.8.2.18981