Oxidative stress and apoptosis: a new treatment paradigm in cancer.

@article{Engel2006OxidativeSA,
  title={Oxidative stress and apoptosis: a new treatment paradigm in cancer.},
  author={Ryan H Engel and A. Evens},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2006},
  volume={11},
  pages={
          300-12
        }
}
Redox regulation has been shown to be an important component of malignant cell survival. Tipping the cellular redox balance through pharmacologic regulation in favor of increasing intracellular reactive oxygen species (ROS) and/or depleting protective reducing metabolites (such as glutathione and nicotinamide adenine dinucleotide phosphate) may lead to oxidative stress and resultant induction of apoptosis for the treatment of cancer. We review the biology and importance of ROS with regard to… Expand
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