Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle.

@article{Mahoney2006OxidativeSA,
  title={Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle.},
  author={Douglas J. Mahoney and Jan Jacek Kaczor and Jacqueline M. Bourgeois and Nobuo Yasuda and Mark A Tarnopolsky},
  journal={Muscle & nerve},
  year={2006},
  volume={33 6},
  pages={809-16}
}
Amyotrophic lateral sclerosis (ALS) is caused by motor neuron loss in the spinal cord, but the mechanisms responsible are not known. Ubiquitous transgenic overexpression of copper/zinc superoxide dismutase (SOD1) mutations causing familial ALS (SOD1mut) leads to an ALS phenotype in mice; however, restricted expression of SOD1mut in neurons alone is not sufficient to cause this phenotype, suggesting that non-neuronal SOD1mut expression is also required for disease manifestation. Recently… CONTINUE READING

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