Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy.

@article{Ziegler2004OxidativeSA,
  title={Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy.},
  author={Dan Ziegler and C Sohr and Jaffar Nourooz-Zadeh},
  journal={Diabetes care},
  year={2004},
  volume={27 9},
  pages={
          2178-83
        }
}
OBJECTIVE Oxidative stress resulting from enhanced free-radical formation and/or a defect in antioxidant defenses has been implicated in the pathogenesis of experimental diabetic neuropathy. The objective of this study was to evaluate plasma levels of various biomarkers of oxidative stress in diabetic subjects in relation to the presence or absence of polyneuropathy (PN) and/or cardiovascular autonomic neuropathy (CAN). RESEARCH DESIGN AND METHODS Plasma 8-iso-prostaglandin F(2alpha) (8-iso… 

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STUDY OF MALONDIALDEHYDE AS OXIDATIVE STRESS AND SUPEROXIDE DISMUTASE AS ENZYMATIC ANTIOXIDANT IN TYPE II DIABETES MELLITUS PATIENTS WITH AND WITHOUT PERIPHERAL NEURITIS.

Long standing diabetes and poor glycemic control is associated with decreased serum superoxide dismutase and increased plasma malondialdehyde, which can be considered as markers for diabetic control and diabetic peripheral neuropathy complications in type II diabetes.

Oxidative stress predicts progression of peripheral and cardiac autonomic nerve dysfunction over 6 years in diabetic patients

Increased plasma superoxide generation predicted the decline in sensory and cardiac autonomic nerve function and mortality over 6 years in diabetic patients, but larger studies are required for confirmation.

Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function

Diabetic polyneuropathy is defined as peripheral nerve dysfunction, and composite scores combined with nerve conduction studies are the most reliable to identify early DPN.

Association Of Poor Glycemic Control With Increased Lipid Peroxidation And Reduced Antioxidant Vitamin Status In Diabetic Neuropathy

Findings indicate in diabetic neuropathy oxidative stress is inversely related to the glycemic control, which could be the unifying mechanism that leads to nervous system damage causing diabetic Neuropathy.

Lower serum extracellular superoxide dismutase levels are associated with polyneuropathy in recent-onset diabetes

Several biomarkers of oxidative stress are altered in recent-onset diabetes, with only a lower SOD3 concentration being linked to the presence of DSPN, suggesting a role for reduced extracellular antioxidative defense against superoxide in the early development of D SPN.

Antioxidant Strategies in the Management of Diabetic Neuropathy

Different strategies for managing diabetic neuropathy which rely on exogenous antioxidants are examined, which are likely to improve nerve dysfunction in diabetes by acting directly against oxidative damage.

Atherothrombosis and oxidative stress: the connection and correlation in diabetes

It would appear that there is a complex link between GSH and D-dimer, which are part of an emerging array of biomarkers associated with diabetes, which led to the proposal of a two-part process of atherosclerosis that reconciles previous contradictory findings.

The Role of Oxidative Stress in Peripheral Neuropathy

Though further research is necessary to better understand the underlying mechanism, it is evident that oxidative stress is implicated in the pathogenesis of – or is at least systematically present in – PN.

Assessment of plasma antioxidant levels in type 2 diabetes patients

Estimating antioxidant status in the form of estimation of plasma/serum Zinc, Ascorbic acid, Albumin, Uric acid & Total bilirubin levels with antioxidant enzymes would greatly help in preventing or postponing the onset of diabetes.
...

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