Oxidative stress and adenine nucleotide control of mitochondrial permeability transition.

@article{Kantrow2000OxidativeSA,
  title={Oxidative stress and adenine nucleotide control of mitochondrial permeability transition.},
  author={Stephen P Kantrow and Lynn G Tatro and Claude A. Piantadosi},
  journal={Free radical biology & medicine},
  year={2000},
  volume={28 2},
  pages={251-60}
}
Mitochondria can initiate apoptosis by releasing cytochrome c after undergoing a calcium-dependent permeability transition (MPT). Although the MPT is enhanced by oxidative stress and prevented by adenine nucleotides such as adenosine 5'-diphosphate (ADP), the hypothesis has not been tested that oxidants regulate the effects of exogenous adenine nucleotides on the MPT and cytochrome c release. We found that cytochrome c release from intact rat liver mitochondria depended strictly on pore opening… CONTINUE READING

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