Oxidative stress and BDNF as possible markers for the severity of crack cocaine use in early withdrawal

  title={Oxidative stress and BDNF as possible markers for the severity of crack cocaine use in early withdrawal},
  author={Anne Orgle Sordi and Fl{\'a}vio Pechansky and F{\'e}lix Henrique Paim Kessler and Fl{\'a}vio Kapczinski and Bianca Pfaffenseller and Carolina Gubert and Bianca Wollenhaupt de Aguiar and Joana Corr{\^e}a de Magalh{\~a}es Narvaez and Felipe Ornell and L{\'i}sia von Diemen},
An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and impairment caused by substance abuse. This study aims to evaluate alteration of TBARS and BDNF levels among crack cocaine users during early drug withdrawal and its relationship to severity of… CONTINUE READING


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