Oxidative stress adaptation in aggressive prostate cancer may be counteracted by the reduction of glutathione reductase

@inproceedings{Freitas2012OxidativeSA,
  title={Oxidative stress adaptation in aggressive prostate cancer may be counteracted by the reduction of glutathione reductase},
  author={Mariana O Freitas and In{\^e}s Baldeiras and Teresa Proença and Vera Alves and Anabela Mota-Pinto and Ana Bela Sarmento-Ribeiro},
  booktitle={FEBS open bio},
  year={2012}
}
Oxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HPV10 (from metastasis and from localized cancer, respectively) and RWPE1 cells derived… CONTINUE READING

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