Oxidative stress: oxidants and antioxidants

  title={Oxidative stress: oxidants and antioxidants},
  author={Helmut Sies},
  journal={Experimental Physiology},
  • H. Sies
  • Published 1997
  • Chemistry, Medicine
  • Experimental Physiology
An imbalance between oxidants and antioxidants in favour of the oxidants, potentially leading to damage, is termed ‘oxidative stress’. Oxidants are formed as a normal product of aerobic metabolism but can be produced at elevated rates under pathophysiological conditions. Antioxidant defense involves several strategies, both enzymatic and non‐enzymatic. In the lipid phase, tocopherols and carotenes as well as oxy‐carotenoids are of interest, as are vitamin A and ubiquinols. In the aqueous phase… Expand

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