Oxidative stress: free radical production in neural degeneration.

  title={Oxidative stress: free radical production in neural degeneration.},
  author={Mario E. G{\"o}tz and Gabriella K{\"u}nig and Peter Franz Riederer and Moussa B. H. Youdim},
  journal={Pharmacology & therapeutics},
  volume={63 1},
It is not yet established whether oxidative stress is a major cause of cell death or simply a consequence of an unknown pathogenetic factor. Concerning chronic diseases, as Parkinson's and Alzheimer's disease are assumed to be, it is possible that a gradual impairment of cellular defense mechanisms leads to cell damage because of toxic substances being increasingly formed during normal cellular metabolism. This point of view brings into consideration the possibility that, besides exogenous… CONTINUE READING