Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes.

@article{Krumschnabel2005OxidativeSM,
  title={Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes.},
  author={Gerhard Krumschnabel and Claudia Manzl and Christian Berger and Bettina Hofer},
  journal={Toxicology and applied pharmacology},
  year={2005},
  volume={209 1},
  pages={62-73}
}
We have previously shown that, in trout hepatocytes, exposure to a high dose of copper (Cu) leads to disruption of Ca(2+) homeostasis and elevated formation of reactive oxygen species (ROS), with the latter ultimately causing cell death. In the present study, we aimed at identifying, using a lower Cu concentration, the role of mitochondria in this scenario, the potential involvement of the mitochondrial permeability transition (MPT), and the mode of cell death induced by the metal. Incubation… CONTINUE READING
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