Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging.

@article{Lee2007OxidativeSM,
  title={Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging.},
  author={Hsin-Chen Lee and Yau-Huei Wei},
  journal={Experimental biology and medicine},
  year={2007},
  volume={232 5},
  pages={592-606}
}
A wide spectrum of alterations in mitochondria and mitochondrial DNA (mtDNA) with aging has been observed in animals and humans. These include (i) decline in mitochondrial respiratory function; (ii) increase in mitochondrial production of reactive oxygen species (ROS) and the extent of oxidative damage to DNA, proteins, and lipids; (iii) accumulation of point mutations and large-scale deletions of mtDNA; and (iv) enhanced apoptosis. Recent studies have provided abundant evidence to substantiate… CONTINUE READING
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