Oxidative status of red blood cells, neutrophils, and platelets in paroxysmal nocturnal hemoglobinuria.


OBJECTIVE Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired stem-cell disorder associated with intravascular hemolysis and thrombosis. Hemolysis is caused by the hypersensitivity of PNH-red blood cells (RBC) to complement-mediated lysis due to deficiency in the surface glycosyl phosphatidylinositol-anchored antigens, CD55 and CD59. Thrombosis may be… (More)
DOI: 10.1016/j.exphem.2007.12.003