Oxidative regulation of the Na(+)-K(+) pump in the cardiovascular system.

  title={Oxidative regulation of the Na(+)-K(+) pump in the cardiovascular system.},
  author={Gemma A. Figtree and Galougahi Keyvan Karimi and Chia-chi Liu and Helge H. Rasmussen},
  journal={Free radical biology & medicine},
  volume={53 12},
The Na(+)-K(+) pump is an essential heterodimeric membrane protein, which maintains electrochemical gradients for Na(+) and K(+) across cell membranes in all tissues. We have identified glutathionylation, a reversible posttranslational redox modification, of the Na(+)-K(+) pump's β1 subunit as a regulatory mechanism of pump activity. Oxidative inhibition of the Na(+)-K(+) pump by angiotensin II- and β1-adrenergic receptor-coupled signaling via NADPH oxidase activation demonstrates the relevance… CONTINUE READING
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