Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway.

Abstract

A transition metal-free, oxidative, regioselective cross-coupling between non-functionalized azoles and chromones at C2-position was developed. A broad reaction scope and further transformation of products were demonstrated. The biological evaluation of products revealed a novel class of hedgehog signaling pathway inhibitors. 
DOI: 10.1039/c4cc08376h

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