Oxidative rearrangement processes in the biosynthesis of gilvocarcin V.

  title={Oxidative rearrangement processes in the biosynthesis of gilvocarcin V.},
  author={Tao Liu and Carsten Fischer and Claus Beninga and J{\"u}rgen Rohr},
  journal={Journal of the American Chemical Society},
  volume={126 39},
  • Tao LiuC. Fischer J. Rohr
  • Published 14 September 2004
  • Chemistry, Biology
  • Journal of the American Chemical Society
Gilvocarcin V (GV), an antitumor agent produced by Streptomyces griseoflavus Gö 3592 and various other streptomycetes, is the most important representative of the distinct family of benzo[d]naphtho[1,2-b]pyran-6-one aryl C-glycoside antibiotics, which show excellent antitumor activity and a remarkably low toxicity. The most intriguing step of its biosynthesis is an oxidative rearrangement cascade, in which the C-5/C-6 of an angucyclinone precursor bond is broken. Although this oxidative… 

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