Oxidative rearrangement processes in the biosynthesis of gilvocarcin V.

@article{Liu2004OxidativeRP,
  title={Oxidative rearrangement processes in the biosynthesis of gilvocarcin V.},
  author={T. Liu and C. Fischer and Claus Beninga and J. Rohr},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 39},
  pages={
          12262-3
        }
}
Gilvocarcin V (GV), an antitumor agent produced by Streptomyces griseoflavus Gö 3592 and various other streptomycetes, is the most important representative of the distinct family of benzo[d]naphtho[1,2-b]pyran-6-one aryl C-glycoside antibiotics, which show excellent antitumor activity and a remarkably low toxicity. The most intriguing step of its biosynthesis is an oxidative rearrangement cascade, in which the C-5/C-6 of an angucyclinone precursor bond is broken. Although this oxidative… Expand
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