Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame

@inproceedings{Murata2017OxidativeRO,
  title={Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame},
  author={Jun Murata and Eiichiro Ono and Seigo Yoroizuka and Hiromi Toyonaga and Akira Shiraishi and Shoko Mori and Masayuki Tera and Toshiaki Azuma and Atsushi J. Nagano and Masaru Nakayasu and Masaharu Mizutani and Tatsuya Wakasugi and Masayuki P. Yamamoto and Manabu Horikawa},
  booktitle={Nature Communications},
  year={2017}
}
Abstract(+)-Sesamin, (+)-sesamolin, and (+)-sesaminol glucosides are phenylpropanoid-derived specialized metabolites called lignans, and are rich in sesame (Sesamum indicum) seed. Despite their renowned anti-oxidative and health-promoting properties, the biosynthesis of (+)-sesamolin and (+)-sesaminol remained largely elusive. Here we show that (+)-sesamolin deficiency in sesame is genetically associated with the deletion of four C-terminal amino acids (Del4C) in a P450 enzyme CYP92B14 that… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

T Laursen
  • Science 354,
  • 2016

Direct evidence for Metabolon Formation and Substrate Channeling in Recombinant TCA Cycle Enzymes

B Bulutoglu
  • ACS Chem. Biol
  • 2016

Genetic distance of inbred lines of Chinese cabbage and its relationship to heterosis

K Kawamura
  • Plant Gene 5,
  • 2016

Identification of protein-protein interactions of isoflavonoid biosynthetic enzymes with 2-hydroxyisoflavanone synthase in soybean (Glycine max (L.) Merr.)

T Waki
  • Biochem. Biophys. Res
  • 2016

Comparative effects of sesame seeds differing in lignan contents and composition on fatty acid oxidation in rat liver

T Ide
  • J. Oleo. Sci
  • 2015

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