Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame

  title={Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame},
  author={Jun Murata and Eiichiro Ono and Seigo Yoroizuka and Hiromi Toyonaga and Akira Shiraishi and Shoko Mori and Masayuki Tera and Toshiaki Azuma and Atsushi J. Nagano and Masaru Nakayasu and Masaharu Mizutani and Tatsuya Wakasugi and Masayuki P. Yamamoto and Manabu Horikawa},
  booktitle={Nature Communications},
Abstract(+)-Sesamin, (+)-sesamolin, and (+)-sesaminol glucosides are phenylpropanoid-derived specialized metabolites called lignans, and are rich in sesame (Sesamum indicum) seed. Despite their renowned anti-oxidative and health-promoting properties, the biosynthesis of (+)-sesamolin and (+)-sesaminol remained largely elusive. Here we show that (+)-sesamolin deficiency in sesame is genetically associated with the deletion of four C-terminal amino acids (Del4C) in a P450 enzyme CYP92B14 that… CONTINUE READING
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