Oxidative protein labeling in mass-spectrometry-based proteomics

  title={Oxidative protein labeling in mass-spectrometry-based proteomics},
  author={Julien Roeser and Rainer Bischoff and Andries P. Bruins and Hjalmar P. Permentier},
  booktitle={Analytical and bioanalytical chemistry},
Oxidation of proteins and peptides is a common phenomenon, and can be employed as a labeling technique for mass-spectrometry-based proteomics. Nonspecific oxidative labeling methods can modify almost any amino acid residue in a protein or only surface-exposed regions. Specific agents may label reactive functional groups in amino acids, primarily cysteine, methionine, tyrosine, and tryptophan. Nonspecific radical intermediates (reactive oxygen, nitrogen, or halogen species) can be produced by… CONTINUE READING


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