Oxidative protein damage causes chromium toxicity in yeast.

  title={Oxidative protein damage causes chromium toxicity in yeast.},
  author={Edward R Sumner and Anupama Shanmuganathan and Theodora C. Sideri and Sylvia A Willetts and John Edgar Houghton and Simon V Avery},
  volume={151 Pt 6},
Oxidative damage in microbial cells occurs during exposure to the toxic metal chromium, but it is not certain whether such oxidation accounts for the toxicity of Cr. Here, a Saccharomyces cerevisiae sod1Delta mutant (defective for the Cu,Zn-superoxide dismutase) was found to be hypersensitive to Cr(VI) toxicity under aerobic conditions, but this phenotype was suppressed under anaerobic conditions. Studies with cells expressing a Sod1p variant (Sod1(H46C)) showed that the superoxide dismutase… CONTINUE READING
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