Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.

@article{Przedborski2001OxidativePM,
  title={Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.},
  author={Serge E. Przedborski and Qianfa Chen and Miquel Vila and Benoit I Giasson and R Djaldatti and Slobodanka Vukosavi{\'c} and Jos{\'e} Maria de Souza and Vernice R. Jackson-Lewis and Virginia M-Y Lee and Harry Ischiropoulos},
  journal={Journal of neurochemistry},
  year={2001},
  volume={76 2},
  pages={637-40}
}
Structural and functional alterations of alpha-synuclein is a presumed culprit in the demise of dopaminergic neurons in Parkinson's disease (PD). Alpha-synuclein mutations are found in familial but not in sporadic PD, raising the hypothesis that effects similar to those of familial PD-linked alpha-synuclein mutations may be achieved by oxidative post-translational modifications. Here, we show that wild-type alpha-synuclein is a selective target for nitration following peroxynitrite exposure of… CONTINUE READING

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