Oxidative phosphorylation revisited

@article{Nath2015OxidativePR,
  title={Oxidative phosphorylation revisited},
  author={S. Nath and J. Villadsen},
  journal={Biotechnology and Bioengineering},
  year={2015},
  volume={112}
}
The fundamentals of oxidative phosphorylation and photophosphorylation are revisited. New experimental data on the involvement of succinate and malate anions respectively in oxidative phosphorylation and photophosphorylation are presented. These new data offer a novel molecular mechanistic explanation for the energy coupling and ATP synthesis carried out in mitochondria and chloroplast thylakoids. The mechanism does not suffer from the flaws in Mitchell's chemiosmotic theory that have been… Expand
Two-ion theory of energy coupling in ATP synthesis rectifies a fundamental flaw in the governing equations of the chemiosmotic theory.
  • S. Nath
  • Chemistry, Medicine
  • Biophysical chemistry
  • 2017
TLDR
It is concluded that the timely availability after a 25-year research struggle of Nath's torsional mechanism of energy transduction and ATP synthesis is a rational alternative that has the power to solve the problems arising from the past, and also meet present and future challenges in this important interdisciplinary field of research. Expand
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  • 2017
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  • S. Nath
  • Chemistry, Medicine
  • Biophysical chemistry
  • 2019
TLDR
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The thermodynamic efficiency of ATP synthesis in oxidative phosphorylation.
  • S. Nath
  • Chemistry, Medicine
  • Biophysical chemistry
  • 2016
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  • S. Nath
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  • Chemistry, Medicine
  • Biophysical chemistry
  • 2018
TLDR
All results have been found to be inconsistent with Mitchell's chemiosmotic theory and are shown to be in agreement with Nath's torsional mechanism of energy transduction and ATP synthesis. Expand
Entropy Production and Its Application to the Coupled Nonequilibrium Processes of ATP Synthesis
  • S. Nath
  • Computer Science, Medicine
  • Entropy
  • 2019
TLDR
It is concluded that, twenty years since its first proposal, Nath’s torsional mechanism of energy transduction and ATP synthesis is now well poised to catalyze the progress of experimental and theoretical research in this interdisciplinary field. Expand
Modern theory of energy coupling and ATP synthesis. Violation of Gauss's law by the chemiosmotic theory and validation of the two-ion theory.
  • S. Nath
  • Chemistry, Medicine
  • Biophysical chemistry
  • 2019
TLDR
It is proved from first principles that the original physical arguments and calculations made in support of steady state electrogenic ion transfer and chemiosmosis violate Gauss's law. Expand
Molecular mechanistic insights into uncoupling of ion transport from ATP synthesis.
  • S. Nath
  • Chemistry, Medicine
  • Biophysical chemistry
  • 2018
TLDR
The pharmacological consequences of the analysis of uncoupling are discussed, with particular reference to the mode of action of the anti-tuberculosis drug bedaquiline that specifically targets the c-subunit of the F1FO-ATP synthase and uncouples respiration from ATP synthesis in Mycobacterium tuberculosis. Expand
Optimality principle for the coupled chemical reactions of ATP synthesis and its molecular interpretation
Abstract Metabolic energy obtained from the coupled chemical reactions of oxidative phosphorylation (OX PHOS) is harnessed in the form of ATP by cells. We experimentally measured thermodynamic forcesExpand
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Beyond the Chemiosmotic Theory: Analysis of Key Fundamental Aspects of Energy Coupling in Oxidative Phosphorylation in the Light of a Torsional Mechanism of Energy Transduction and ATP Synthesis—Invited Review Part 1
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