Oxidative phosphorylation and its coupling to mitochondrial creatine and adenylate kinases in human gastric mucosa.

@article{Gruno2006OxidativePA,
  title={Oxidative phosphorylation and its coupling to mitochondrial creatine and adenylate kinases in human gastric mucosa.},
  author={Marju Gruno and Nadezhda Peet and Evelin Seppet and Lumme Kadaja and Kalju Paju and Margus Eimre and Ehte Orlova and Margot Peetsalu and Andres Tein and Jaan Soplepmann and Uwe Schlattner and Ants Peetsalu and Enn K. Seppet},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2006},
  volume={291 4},
  pages={R936-46}
}
Energy metabolism in gastrobiopsy specimens of the antral and corpus mucosa, treated with saponin to permeabilize the cells, was studied in patients with gastric diseases. The results show twice lower oxidative capacity in the antral mucosa than in the corpus mucosa and the relative deficiency of antral mitochondria in complex I. The mucosal cells expressed mitochondrial and cytosolic isoforms of creatine kinase and adenylate kinase (AK). Creatine (20 mM) and AMP (2 mM) markedly stimulated… CONTINUE READING

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