Oxidative pathways as a drug target for the treatment of autism

@article{Villagonzalo2010OxidativePA,
  title={Oxidative pathways as a drug target for the treatment of autism},
  author={Kristi-Ann Villagonzalo and Seetal Dodd and Olivia M. Dean and Kylie M. Gray and Bruce J. Tonge and Michael Berk},
  journal={Expert Opinion on Therapeutic Targets},
  year={2010},
  volume={14},
  pages={1301 - 1310}
}
Importance of the field: Autism is a severe, pervasive developmental disorder, the aetiology of which is poorly understood. Current pharmacological treatment options for autism are often focused on addressing comorbid behavioural problems, rather than core features of the disorder. Investigation of a new treatment approach is needed. Areas covered in this review: Recent research has indicated a possible role of abnormalities in oxidative homeostasis in the pathophysiology of autism, based on… 
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References

SHOWING 1-10 OF 91 REFERENCES
Evidence of Toxicity, Oxidative Stress, and Neuronal Insult in Autism
  • J. Kern, A. Jones
  • Medicine
    Journal of toxicology and environmental health. Part B, Critical reviews
  • 2006
TLDR
The evidence for the case that some children with autism may become autistic from neuronal cell death or brain damage sometime after birth as result of insult is discussed; and the hypotheses that toxicity and oxidative stress may be a cause of neuronal insult in autism are addressed.
Oxidative stress in autism.
  • W. McGinnis
  • Psychology, Medicine
    Alternative therapies in health and medicine
  • 2004
TLDR
The role of oxidative stress may help illuminate the pathophysiology of autism, its environmental and genetic influences, new treatments, and prevention, and how anti-oxidant nutrients are used in the contemporary treatment of autism.
Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
  • M. Herbert
  • Biology, Medicine
    Current opinion in neurology
  • 2010
TLDR
Prevalence, genetic, exposure, and pathophysiological evidence all suggest a role for environmental factors in the inception and lifelong modulation of ASD, which supports the need for seeking targets for early and ongoing medical prevention and treatment of ASD.
Folate and methionine metabolism in autism: a systematic review.
TLDR
It is concluded that further research is required with appropriately standardized and adequately powered study designs before any definitive conclusions can be made about the role for a dysfunctional folate-methionine pathway in the etiology of autism.
Oxidative stress in autism.
  • A. Chauhan, V. Chauhan
  • Medicine
    Pathophysiology : the official journal of the International Society for Pathophysiology
  • 2006
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
TLDR
An increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.
Mitochondrial dysfunction in autism spectrum disorders: a population-based study.
TLDR
Five of 11 patients studied were classified with definite mitochondrial respiratory chain disorder, suggesting that this might be one of the most common disorders associated with autism and warranting further investigation.
How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis.
TLDR
A "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.
Glutathione: a novel treatment target in psychiatry.
TLDR
The multidimensional evidence that currently exists for oxidative stress mechanisms in psychiatric disorders is outlined and glutathione is discussed as a promising novel therapeutic target.
Increased excretion of a lipid peroxidation biomarker in autism.
TLDR
The results suggest that the lipid peroxidation biomarker is increased in this cohort of autisticChildren, especially in the subgroup of autistic children.
...
1
2
3
4
5
...