Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

@article{Malkus2009OxidativeMM,
  title={Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle},
  author={Kristen A. Malkus and Elpida Tsika and Harry Ischiropoulos},
  journal={Molecular Neurodegeneration},
  year={2009},
  volume={4},
  pages={24 - 24}
}
While numerous hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of neurodegenerative diseases, the theory of oxidative stress has received considerable support. Although many correlations have been established and encouraging evidence has been obtained, conclusive proof of causation for the oxidative stress hypothesis is lacking and potential cures have not emerged. Therefore it is likely that other factors, possibly in coordination with oxidative… CONTINUE READING
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