Oxidative modification of low-density lipoproteins and the inhibition of relaxations mediated by endothelium-derived nitric oxide in rabbit aorta.

@article{Plane1992OxidativeMO,
  title={Oxidative modification of low-density lipoproteins and the inhibition of relaxations mediated by endothelium-derived nitric oxide in rabbit aorta.},
  author={Frances Plane and Karl Richard Bruckdorfer and P Ben Kerr and Alan Steuer and Michael Graham Jacobs},
  journal={British journal of pharmacology},
  year={1992},
  volume={105 1},
  pages={216-22}
}
1. The mechanism by which Cu(2+)-oxidized low-density lipoproteins (oxLDL) inhibit acetylcholine (ACh)-evoked relaxations mediated by endothelium-derived nitric oxide (EDRF) in rabbit aortic rings was investigated. The proposed role of lysophosphatidylcholine (LPC) in the inhibition was also studied. 2. The kinetics of lipid peroxidation of native low-density lipoproteins (LDL) from individual donors, as measured by changes in conjugated diene concentration, were related to the inhibitory… CONTINUE READING
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