Oxidative modification of low-density lipoproteins in atherothrombosis.

  title={Oxidative modification of low-density lipoproteins in atherothrombosis.},
  author={Paul Holvoet},
  journal={Acta cardiologica},
  volume={53 5},
Oxidative modification of LDL may occur via mechanisms, which are either dependent or independent of lipid peroxidation. Peroxidation of lipids in LDL, either initiated by radicals or catalysed by myeloperoxidase, results in the generation of aldehydes which substitute lysine residues in the apolipoprotein B-100 moiety and thus in the generation of oxidised LDL. Phospholipase activity, prostaglandin synthesis and platelet adhesion/activation are associated with the release of aldehydes which… CONTINUE READING