Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis.

@article{Matsuura2006OxidativeMO,
  title={Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis.},
  author={Eiji Matsuura and Kazuko Kobayashi and Masako Tabuchi and Luis R. Lopez},
  journal={Progress in lipid research},
  year={2006},
  volume={45 6},
  pages={466-86}
}
Oxidized low-density lipoprotein (oxLDL) is thought to promote atherosclerosis through complex inflammatory and immunologic mechanisms that lead to lipid dysregulation and foam cell formation. Recent findings suggested that oxLDL forms complexes with beta2-glycoprotein I (beta2GPI) and/or C-reactive protein (CRP) in the intima of atherosclerotic lesions. Autoantibodies against oxLDL/beta2GPI complexes occur in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome… CONTINUE READING

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