Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities.

@article{Khn1994OxidativeMO,
  title={Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities.},
  author={Hartmut K{\"u}hn and Jutta Belkner and Hiroaki Suzuki and Sh{\^o}zo Yamamoto},
  journal={Journal of lipid research},
  year={1994},
  volume={35 10},
  pages={
          1749-59
        }
}
Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. We studied the interaction of lipoxygenases of different positional specificities with human lipoproteins and found that the arachidonate 15-lipoxygenases of rabbit and humans and the arachidonate 12-lipoxygenase of porcine leukocytes oxygenate lipoproteins as indicated by the formation of oxygenated lipids and changes in electrophoretic mobility of low density lipoprotein. The… CONTINUE READING

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