Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha.

@article{Nagakawa2005OxidativeMD,
  title={Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha.},
  author={Yuichi Nagakawa and George Melville Williams and Qizhi Zheng and Akihiko Tsuchida and Tatsuya Aoki and Robert R. Montgomery and Andrew S. Klein and Zhaoli Sun},
  journal={Hepatology},
  year={2005},
  volume={42 1},
  pages={208-15}
}
An orthotopic liver transplant model in the rat was used to evaluate the role of tumor necrosis factor alpha (TNF-alpha) in liver transplant rejection. There were significantly increased levels of TNF-alpha mRNA and parallel increases in 8-hydroxy-2' deoxyguanosine (8-OHdG) indicative of oxidative DNA damage present 7 to 12 days after transplantation. Cells staining positively for 8-OHdG were localized to the cytoplasm of hepatocytes adjacent to the TNF-alpha expressing inflammatory cells in… CONTINUE READING

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