Oxidative metabolism of flunarizine in rat liver microsomes.


The oxidative metabolism of flunarizine [1-[bis(4-fluorophenyl)-methyl]-4-(3-phenyl-2-propenyl)piperazine, FZ] to 1-[bis-(4-fluorophenyl)methyl]piperazine (M-1), 1-[bis(4-fluorophenyl)methyl]-4-[3-(4'-hydroxyphenyl)-2- propenyl]piperazine (M-2) and 4,4'-difluorobenzophenone (M-3) has been studied in liver microsomes of Wistar and Dark Agouti (DA) rats… (More)


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@article{Kariya1992OxidativeMO, title={Oxidative metabolism of flunarizine in rat liver microsomes.}, author={Shuji Kariya and Shuji Isozaki and Shintaro Narimatsu and T. Suzuki}, journal={Research communications in chemical pathology and pharmacology}, year={1992}, volume={78 1}, pages={85-95} }