Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes.

Abstract

Conjugation with glucuronic acid is a prevalent metabolic pathway of orally administrated curcumin, the bioactive diphenol of the spice turmeric. The major in vitro degradation reaction of curcumin is autoxidative transformation resulting in oxygenation and cyclization of the heptadienedione chain to form cyclopentadione derivatives. Here we show that… (More)
DOI: 10.1016/j.bcp.2017.03.002

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