Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.

  title={Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.},
  author={Melissa V. Turman and Philip J. Kingsley and Carol A. Rouzer and Benjamin F Cravatt and Lawrence J Marnett},
  volume={47 12},
A novel class of lipids, N-acyltaurines, was recently discovered in fatty acid amide hydrolase knockout mice. In some peripheral tissues, such as liver and kidney, N-acyltaurines with long, polyunsaturated acyl chains are most prevalent. Polyunsaturated fatty acids are converted to a variety of signaling molecules by cyclooxygenases (COXs) and lipoxygenases (LOXs). The ability of COXs and LOXs to oxygenate arachidonoyltaurine was evaluated to gain insight into the potential metabolic fate of N… CONTINUE READING
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