Oxidative mechanisms in the toxicity of metal ions.

  title={Oxidative mechanisms in the toxicity of metal ions.},
  author={Sidney J Stohs and Divya Bagchi},
  journal={Free radical biology & medicine},
  volume={18 2},
The role of reactive oxygen species, with the subsequent oxidative deterioration of biological macromolecules in the toxicities associated with transition metal ions, is reviewed. Recent studies have shown that metals, including iron, copper, chromium, and vanadium undergo redox cycling, while cadmium, mercury, and nickel, as well as lead, deplete glutathione and protein-bound sulfhydryl groups, resulting in the production of reactive oxygen species as superoxide ion, hydrogen peroxide, and… CONTINUE READING
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