Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.

@article{Qiao2005OxidativeMC,
  title={Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.},
  author={Dan Qiao and Frederic J. Seidler and Theodore A. Slotkin},
  journal={Toxicology and applied pharmacology},
  year={2005},
  volume={206 1},
  pages={
          17-26
        }
}
Nicotine and chlorpyrifos are developmental neurotoxicants that, despite their differences in structure and mechanism of action, share many aspects for damage to the developing brain. Both are thought to generate oxidative radicals; in the current study, we evaluated their ability to produce lipid peroxidation in two in vitro models of neural cell development (PC12 and SH-SY5Y cells) and for nicotine, with treatment of adolescent rats in vivo. Nicotine and chlorpyrifos, in concentrations… CONTINUE READING
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