Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells.

OBJECTIVE To explore the impact of oxidative insults on mitochondrial dynamics. In mammalian cells, oxidative insults activate stress response pathways including inflammation, cytokine secretion, and apoptosis. Intriguingly, mitochondria are emerging as a sensitive network that may function as an early indicator of subsequent cellular stress responses… CONTINUE READING