Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.

@article{Fernandes2008OxidativeIO,
  title={Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.},
  author={Alexandre Furtado Fernandes and Jilin Zhou and Xinyu Zhang and Qingning Bian and Janet R Sparrow and Allen Taylor and Paulo C.M. Pereira and F M Shang},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 30},
  pages={20745-53}
}
Oxidative stress and inflammation are implicated in the pathogenesis of many age-related diseases. Stress-induced overproduction of inflammatory cytokines, such as interleukin-8 (IL-8), is one of the early events of inflammation. The objective of this study was to elucidate mechanistic links between oxidative stress and overproduction of IL-8 in retinal pigment epithelial (RPE) cells. We found that exposure of RPE cells to H(2)O(2), paraquat, or A2E-mediated photooxidation resulted in increased… CONTINUE READING
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Oxidative Inactivation of the Proteasome Up-regulates IL-8 20752 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • M. Obin, F. Shang, X. Gong, G. Handelman, J. Blumberg, A. Taylor
  • M oash U niersity (C A U L ) on D ecem er 15,
  • 2008

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