Oxidative impairment of plasma and skeletal muscle sarcoplasmic reticulum in rats with adjuvant arthritis - effects of pyridoindole antioxidants.

@article{Strosova2008OxidativeIO,
  title={Oxidative impairment of plasma and skeletal muscle sarcoplasmic reticulum in rats with adjuvant arthritis - effects of pyridoindole antioxidants.},
  author={Miriam K. Strosova and Iveta Tomaskova and Silvester Poni{\vs}t and Katar{\'i}na Bauerov{\'a} and Janka Karlovsk{\'a} and Corinne M Spickett and Lubica Horakova},
  journal={Neuro endocrinology letters},
  year={2008},
  volume={29 5},
  pages={706-11}
}
OBJECTIVES To study possible oxidation of proteins and lipids in plasma and sarcoplasmic reticulum (SR) from skeletal muscles and to assess the effects of pyridoindole antioxidants in rats with adjuvant arthritis (AA) and to analyze modulation of Ca-ATPase activity from SR (SERCA). METHODS SR was isolated by ultracentrifugation, protein carbonyls in plasma and SR were determined by ELISA. Lipid peroxidation was analyzed by TBARS determination and by mass spectrometry. ATPase activity of SERCA… CONTINUE READING

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