Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies.

@article{Gyanda2013OxidativeFA,
  title={Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies.},
  author={Reena Gyanda and Jayati Banerjee and Yi-Pin Chang and Angela M Phillips and Lawrence Toll and Christopher J. Armishaw},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2013},
  volume={19 1},
  pages={16-24}
}
α-Conotoxins are peptide neurotoxins that selectively inhibit various subtypes of nicotinic acetylcholine receptors. They are important research tools for studying numerous pharmacological disorders, with profound potential for developing drug leads for treating pain, tobacco addiction, and other conditions. They are characterized by the presence of two disulfide bonds connected in a globular arrangement, which stabilizes a bioactive helical conformation. Despite extensive structure-activity… CONTINUE READING