Oxidative degradation of bilirubin produces vasoactive compounds.

  title={Oxidative degradation of bilirubin produces vasoactive compounds.},
  author={Kamil R Kranc and Gail J. Pyne and Lei Tao and Timothy D W Claridge and David A Harris and Thomas A D Cadoux-Hudson and Jonathan J Turnbull and Christopher J. Schofield and J. F. Clark},
  journal={European journal of biochemistry},
  volume={267 24},
Subarachnoid haemorrhage is often followed by haemolysis and concomitant oxidative stress, and is frequently complicated by pathological vasoconstriction or cerebral vasospasm. It is known that upregulation of haem oxygenase (HO-1) is induced by oxidative stress and results in release of biliverdin and bilirubin (BR), which are scavengers of reactive oxygen species (ROS). Here we report biomimetic studies aimed at modelling pathological conditions leading to oxidative degradation of BR… CONTINUE READING


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