Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone

@inproceedings{Leung2011OxidativeDI,
  title={Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone},
  author={J. C. K. Leung and Loretta Y. Y. Chan and Sydney C. W. Tang and Man-fai Lam and C P Chow and Ai-Ing Lim and K N Lai},
  booktitle={Journal of Translational Medicine},
  year={2011}
}
Inhibition of the renin-angiotensin-aldosterone system (RAAS) slows down the progression of chronic renal diseases (CKD) including IgA nephropathy (IgAN). Herein, we studied the pathogenetic roles of aldosterone (Aldo) in IgAN. Human mesangial cells (HMC) was activated with polymeric IgA (pIgA) from IgAN patients and the effects on the expression of RAAS components and TGF-β synthesis examined. To study the roles of RAAS in the glomerulotubular communication, proximal tubular epithelial cells… CONTINUE READING
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